Narcotic action at the molecular level

Winning the COVID-19 War: McKinsey & Company's Proposed Plan for Action at the Local Level

McKinsey & Company, a global management consulting firm, has published a document for local authorities to introduce and explain strategies and actions to combat COVID-19. This document, by evaluating the current situation and considering some degree of contagion for at least 12-18 months, presents three strategies for local authorities to deal effectively with the virus and safeguard the life ...

Mass action at the single-molecule level.

We developed a system to reversibly encapsulate small numbers of molecules in an array of nanofabricated "dimples". This system enables highly parallel, long-term, and attachment-free studies of molecular dynamics via single-molecule fluorescence. In studies of bimolecular reactions of small numbers of confined molecules, we see phenomena that, while expected from basic statistical mechanics, a...

Ferroelectricity at molecular level

The mode of action of promethazine in potentiating narcotic drugs.

Evidence is presented from more than 300 subjects to show that promethazine potentiates the action of six different narcotics (morphine, pethidine, oxymorphone, hydromorphone, fentanyl and pentazocine). In each instance there was prolongation rather than deepening of the narcotic action. Such an effect is consistent with the known membrane-stabilizing action of promethazine and is likely to occ...

An immunological approach to study gonadotropin action at the cellular and molecular level.

The last two decades have seen a rapid development of a variety of new techniques and probes to understand the regulatory functions of hormones. One such tool is antibodies against hormones. Antibodies against the gonadotropins Lutropin (LH) and Follitropin (FSH), in addition to showing hormonal specificity, react with LH and FSH of a variety of other species (1-3). This property has been found...